goldfly
<B>if my thought dreams could be seen</B>
Dumbass thethe: “fat people man”
The Coronavirus, not the beer
- Thread starter Runnin
- Start date
Dumbass thethe: “fat people man”
goldfly
<B>if my thought dreams could be seen</B>
“Mass firings” hahahahaha
They are actually saying to stop making the vaccine political.
Which is the correct answer.
sturg33
I
... Wut
goldfly
<B>if my thought dreams could be seen</B>
They is he
And I watched the video. Thanks for explaining that though
Your reply has zero to do with my statement
sturg33
I
What would need to happen for you find mass firings appropriate description?
Some 80,000 people not enough i guess
And not forced to ensure employment like the others.
zbhargrove
Well-known member
Sounds like there is some real promise that could bounce COVID orally. The early study results are very promising. From my buddy Jason who is an ER and research doctor in Boulder Colorado. He does weekly research COVID post updates. It’s long but worth the read IMO:
“COVID Update 10/1/21: Molnupiravir--The Oral Cure to COVID?
First off, apologies to all for the long delay in this latest posting. COVID and huge hospital censuses exhausted me to the point of burnout, so it's taken a while to circulate back to this group. Hopefully I will be here more often (or less often) depending upon the import of today's subject: Merck's molnupiravir.
I'll open with the tl;dr version for those with short attention spans: YES, this drug looks like it could be the one to upend the pandemic. But, yes, we need to be cautious.
I have had the opportunity to review the manuscript (link in comments below) in full. And I have come away surprisingly pleased with the data.
Let's start with the basics, molnupiravir is a molecule that when ingested is converted by our own body's enzymes into a really clever molecule that looks to the machinery of reproduction of viral RNA in the cell like just another building block. The basic building blocks of RNA are similar to DNA with the exception of instead of building with letters ATGC, RNA builds with AUGC (with each letter being part of the four letter alphabet stitched together to create the "recipe" for COVID).
Here's where it gets cool. Molnupiravir tricks the viruses' RNA into thinking it is either a "U" or "C" and instead it gets inserted. Picture this...a string of letters spelling a critical part of the spike protein (I'm making this up a little)--AAGUUGCCC...but instead it now reads AAGMMGMMM. This new strand of RNA is nonsense and won't code for proper building of proteins. And boom, now the virus can't replicate.
But does that happen in real life? Well, the current manuscript says 100% yes. How do we know? Volunteers who were COVID+ who received the medication saw viral replication plummet to zero rapidly. And, it appears the loss of viral replication had the effect of improving symptoms compared to placebo with very well tolerated side effects on par with placebo.
If this pans out in subsequent trials, this would effectively stop the spread of COVID in ill patients and that would substantially drop its Ro (r-naught=how infectious a virus is and essentially means how many people get infected from one person with the disease. Natural Ro for delta is close to 8.4 (but factors such as social distancing, masking, and vaccination all affect this value). If Ro gets <<0.5, it could literally mean the end of the pandemic in the first world (though eradication is highly unlikely and we'll be living with SARS-CoV-2 for years still, and 3rd world countries will continue to suffer disproportionately unfortunately).
What makes this study so exciting? First, the experimental and control groups were well-designed and well-matched. The side effects appeared to occur more in the placebo and lower-dose drug groups, and least in the highest dose group (which also had the most robust response). Viral loads were virtually vaporized in the treatment groups, and most in the highest dose group.
Why should we be cautious? The study was small and we don't have comprehensive data on the subjects. For example, while BMI and BMI>30 are both listed, there is no commentary on comorbidities such as diabetes, hypertension, or immunocompromised status. In fact, there is no comment on exclusionary criteria for the trial either, and that, my friends, usually means the group of patients was highly cherry picked. And without those data, it is possible the data are skewed if more patients in the placebo arm had those conditions.
Second: the endpoints were based on viral load clearance, and not on whether or not patients developed long-term COVID, or whether or not these treatments will, by convention, reduce mortality or hospitalization. But that's in part because this was a Phase II trial and that takes a group to test feasibility of the drug in humans. And while it was a randomized control trial, it's outcomes were measuring viral levels and clearance. There is good reason to anticipate that lower viral loads=better outcomes, but this study wasn't powered or designed to answer that.
I will note that the study alludes to a current Phase II/III study that is in progress which will eventually answer those questions. Once those data are available, we will know enough to know if emergency use authorization would be likely. Also, patients who received the treatment were slightly more likely to report that they felt better with the treatment (65% vs 50% in the placebo group).
Third, minorities were poorly represented. The majority of the non-Caucasian subjects were Asian, there were few African Americans, and it is possible there were Latin-x in the study, but that group was labelled "other" and who knows what that means?
Despite this, this is the first oral medication that appears to markedly disrupt replication of SARS-CoV-2. It appears well-tolerated and if the next studies confirm that it reduces hospitalizations, or shortens hospitalizations/reduces deaths, then, yes, this would be the single most important development since vaccines.
An interesting quirk found in the study that I found even more surprising: despite the rapid reduction in viral loads, patients who received the treatment still mounted humoral immunity (read: developed antibodies that provide immunity).
Which brings us back to the bigger issue. While ALL of this is positive, it DOES NOT get us past the need for vaccination. This is a treatment for patients who get infected. Vaccination absolutely reduces symptomatic infection and is the single biggest game changer out there. The only way out of the pandemic is vaccination. However, a treatment that decreases viral load also decreases disease spread and thus increases the likelihood that we could get to herd immunity. But a treatment is almost never as effective as prevention.
So a lot of stars still have to align...more to follow. If all this comes to pass, it is possible life as we once knew it could once again become life as we know it.
Get VACCINATED and wear masks. We've still got a long way to go.”
Link to drug trial study: http://www.medrxiv.org/content/10.1101/2021.06.17.21258639v1.full.pdf?fbclid=IwAR2Jp71eKIb0Ys72s9pJMBj92yytJkCT5SRx0FvyQmMYLXAQAX4WFVI7HyU
Article in Nature: https://www.nature.com/articles/s41594-021-00651-0?fbclid=IwAR0Lu0fpI31GK8YlxcJ1y8Dk8J0U03nMWaiBguSom8yhZpyG5MhUhqR0YTM
“COVID Update 10/1/21: Molnupiravir--The Oral Cure to COVID?
First off, apologies to all for the long delay in this latest posting. COVID and huge hospital censuses exhausted me to the point of burnout, so it's taken a while to circulate back to this group. Hopefully I will be here more often (or less often) depending upon the import of today's subject: Merck's molnupiravir.
I'll open with the tl;dr version for those with short attention spans: YES, this drug looks like it could be the one to upend the pandemic. But, yes, we need to be cautious.
I have had the opportunity to review the manuscript (link in comments below) in full. And I have come away surprisingly pleased with the data.
Let's start with the basics, molnupiravir is a molecule that when ingested is converted by our own body's enzymes into a really clever molecule that looks to the machinery of reproduction of viral RNA in the cell like just another building block. The basic building blocks of RNA are similar to DNA with the exception of instead of building with letters ATGC, RNA builds with AUGC (with each letter being part of the four letter alphabet stitched together to create the "recipe" for COVID).
Here's where it gets cool. Molnupiravir tricks the viruses' RNA into thinking it is either a "U" or "C" and instead it gets inserted. Picture this...a string of letters spelling a critical part of the spike protein (I'm making this up a little)--AAGUUGCCC...but instead it now reads AAGMMGMMM. This new strand of RNA is nonsense and won't code for proper building of proteins. And boom, now the virus can't replicate.
But does that happen in real life? Well, the current manuscript says 100% yes. How do we know? Volunteers who were COVID+ who received the medication saw viral replication plummet to zero rapidly. And, it appears the loss of viral replication had the effect of improving symptoms compared to placebo with very well tolerated side effects on par with placebo.
If this pans out in subsequent trials, this would effectively stop the spread of COVID in ill patients and that would substantially drop its Ro (r-naught=how infectious a virus is and essentially means how many people get infected from one person with the disease. Natural Ro for delta is close to 8.4 (but factors such as social distancing, masking, and vaccination all affect this value). If Ro gets <<0.5, it could literally mean the end of the pandemic in the first world (though eradication is highly unlikely and we'll be living with SARS-CoV-2 for years still, and 3rd world countries will continue to suffer disproportionately unfortunately).
What makes this study so exciting? First, the experimental and control groups were well-designed and well-matched. The side effects appeared to occur more in the placebo and lower-dose drug groups, and least in the highest dose group (which also had the most robust response). Viral loads were virtually vaporized in the treatment groups, and most in the highest dose group.
Why should we be cautious? The study was small and we don't have comprehensive data on the subjects. For example, while BMI and BMI>30 are both listed, there is no commentary on comorbidities such as diabetes, hypertension, or immunocompromised status. In fact, there is no comment on exclusionary criteria for the trial either, and that, my friends, usually means the group of patients was highly cherry picked. And without those data, it is possible the data are skewed if more patients in the placebo arm had those conditions.
Second: the endpoints were based on viral load clearance, and not on whether or not patients developed long-term COVID, or whether or not these treatments will, by convention, reduce mortality or hospitalization. But that's in part because this was a Phase II trial and that takes a group to test feasibility of the drug in humans. And while it was a randomized control trial, it's outcomes were measuring viral levels and clearance. There is good reason to anticipate that lower viral loads=better outcomes, but this study wasn't powered or designed to answer that.
I will note that the study alludes to a current Phase II/III study that is in progress which will eventually answer those questions. Once those data are available, we will know enough to know if emergency use authorization would be likely. Also, patients who received the treatment were slightly more likely to report that they felt better with the treatment (65% vs 50% in the placebo group).
Third, minorities were poorly represented. The majority of the non-Caucasian subjects were Asian, there were few African Americans, and it is possible there were Latin-x in the study, but that group was labelled "other" and who knows what that means?
Despite this, this is the first oral medication that appears to markedly disrupt replication of SARS-CoV-2. It appears well-tolerated and if the next studies confirm that it reduces hospitalizations, or shortens hospitalizations/reduces deaths, then, yes, this would be the single most important development since vaccines.
An interesting quirk found in the study that I found even more surprising: despite the rapid reduction in viral loads, patients who received the treatment still mounted humoral immunity (read: developed antibodies that provide immunity).
Which brings us back to the bigger issue. While ALL of this is positive, it DOES NOT get us past the need for vaccination. This is a treatment for patients who get infected. Vaccination absolutely reduces symptomatic infection and is the single biggest game changer out there. The only way out of the pandemic is vaccination. However, a treatment that decreases viral load also decreases disease spread and thus increases the likelihood that we could get to herd immunity. But a treatment is almost never as effective as prevention.
So a lot of stars still have to align...more to follow. If all this comes to pass, it is possible life as we once knew it could once again become life as we know it.
Get VACCINATED and wear masks. We've still got a long way to go.”
Link to drug trial study: http://www.medrxiv.org/content/10.1101/2021.06.17.21258639v1.full.pdf?fbclid=IwAR2Jp71eKIb0Ys72s9pJMBj92yytJkCT5SRx0FvyQmMYLXAQAX4WFVI7HyU
Article in Nature: https://www.nature.com/articles/s41594-021-00651-0?fbclid=IwAR0Lu0fpI31GK8YlxcJ1y8Dk8J0U03nMWaiBguSom8yhZpyG5MhUhqR0YTM
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goldfly
<B>if my thought dreams could be seen</B>
There isn’t mass firings happening
I really don’t give a **** about your hypotheticals etc
goldfly
<B>if my thought dreams could be seen</B>
That maga has brought anti vax mainstream and somehow stolen it from the dumbest of the far left
Was an unexpected turn I should have seen. Of course they found a stupid as **** opinion and reappropriated to their “movement” of awfulness
sturg33
I
Oh good rebut, per usualy
goldfly
<B>if my thought dreams could be seen</B>
Sure go for it
We all remember how you have twisted those words
It’s still cute to act like maga isn’t taking it cause of dems though lol
goldfly
<B>if my thought dreams could be seen</B>
Thanks
It helps to not play stupid hypothetical/slippery slopes games with people who are frauds
70% of African Americans are MAGA now?
goldfly
<B>if my thought dreams could be seen</B>
92% in news York have gotten at least one shot
There are a little more than 650,000 in healthcare there
So, your math is wrong (I’ll help ya if you can figure that out on your own)
And yes, that small of a percentage isn’t “mass” imo
But you keep fighting king. You have found a good group to try to take this country back 150 years for the dream you want