People like Manchin, Tester, Romney, Murkowski and Collins will determine what passes and what does not. I'm good with that.
And there are a couple more liberal Democrats, Coons and Durbin, who have shown an ability to develop good relationships with people across the aisle.
I think it would be smart to channel as much legislation as possible along those lines. I know my liberal Democratic friends will not like hearing this. But the margins in both the House and Senate imply there is no other way.
The one thing I could see passing along partisan lines is raising taxes on corporations and people making over 400K. That can be folded into the reconciliation process and as such will not need bipartisan support.
Probably the most contentious issue in the near-term will be a bailout of state and local governments to make up for lost revenues. Could become a partisan football. Or a bipartisan spirit might prevail since a lot of red states are hurting. From an economic perspective I think it makes a lot more sense than sending $2,000 checks to people whose finances have hardly been affected by the pandemic. Concentrate the aid on areas and people that have been hurt.